ESIGEM PROTOCOL
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Ethics Approval: Clinical Research Ethics Committee of Galicia (Decision No 2005/295)
Accreditation: Spanish Society of Pediatric Intensive Care of the Spanish Association of Pediatrics (2/11/2005)
Type of Study: Ambispective multicenter
Objectives: To assess the genetic influence on Meningococcal Disease:
- Correlate genetic patterns and forecasts
- Correlate genetic patterns and clinical
Authors protocol Dr. Federico Martinón-Torres
Dra. Sonia Marcos Alonso
Principal Investigators Dr. Angel Carracedo Alvarez
Dra. Sonia Marcos Alonso
Dr. Federico Martinón-Torres
Dr. Jose María Martinón Sánchez
Dr. Antonio Salas Ellacuriaga
Dra. Ana Paula Vega Gliemmo
ESIGEM Coordinator Federico Martinon-Torres
The study will be coordinated from the main research center ( Hospital Clinico Universitario de Santiago ) by the Principal Investigator team.

The Patient recruitment was done through the following centers:
• Hospital Clínico Universitario (Santiago)
• Hospital Universitario de Salamanca
• Hospital da Costa de Burela (Lugo)
• Complejo Hospitalario Cristal-Piñor (Ourense)
• Hospital Parc Paulí de Sabadell
• Hospital Donosita de San Sebastián
• Hospital Ramón y Cajal de Madrid
• Hospital Virgen de la Salud de Toled
• Hospital Virgen de las Nieves de Granada
• Hospital Joan XXIII de Tarragona
• Hospital Universitario Central de Asturias
• Hospital General Universitario de Alicante
• Hospital Torrecárdenas de Almeria
• Complejo Hospitalario Universitario de Vigo
• Complejo Hospitalario de Jaén
• Hospital San Juan de Dios (Barcelona)
• Hospital Infantil “La Fe” de Valencia
• Hospital Marqués de Valdecilla de Santander
• Hospital “Niño Jesús” de Madrid
• Hospital Juan Canalejo de La Coruña
• Hospital Gregorio-Marañon de Madrid
• Hospital Vall d’Hebron (Barcelona)
• Hospital Carlos Haya (Malaga)
• Hospital de Cruces (Vizcaya)
• Hospital Xeral-Calde (Lugo)
• Hospital Reina Sofia (Córdoba)
• Hospital “Virgen del Rocío”(Sevilla)
• Hospital Universitario de Albacete
• Hospital Clínico Universitario de Valencia
• Hospital Puerta del Mar (Cádiz)
• Hospital Virgen del Camino (Navarra)
• Hospital Infantil “La Paz” (Madrid)
• Hospital San Juan de Dios (Barcelona)
• Hospital Virgen de La Arrixaxa (Murcia)
• Hospital Universitario 12 de Octubre (Madrid)
• Hospital Rey Don Jaime (Castellón)
• Hospital San Cecilio (Granada)
• Hospital de Monforte (Lugo)
• Hospital Josep Trueta (Girona)
• Hospital Virxen da Xunqueira (Cee)
• Hospital 9 de Octubre (Valencia)
• Hospital de Sant Pau (Barcelona)
• Hospital Son Dureta (Palma de Mallorca)
• Hospital Arquitecto Marcide (Ferrol)
Euclids-project
Now part of the international consortium Euclids - Childhood Life-threatening Disease Study Infectious prroyecto FP7 funded by a European Union (GA # 279182)

FIS - Instituto Carlos III PI070069
Project Title: Genetics of meningococcal disease: Multicenter study on the mechanisms of genetic protection predisposicióny in pediatric meningococcal infection.
Objective: To establish the genetic basis that predispose or protect against meningococcal disease and that determine their prognosis.
Principal Investigator: Federico Martinon Torres
Study period: 2008 to 2011


Xunta de Galicia 2006PX309
Project Title: Study of mitochondrial DNA in the expression of meningococcal disease
Objective: To analyze the role of the mitochondrial genome in host behavior meningoócica against disease and its possible influence on the susceptibility and prognosis.
Principal Investigator: Antonio Salas Ellacuriaga
Study period: 2006 to 2009


Collaboration agreement University of Santiago de Compostela and Wyeth Pharmaceuticals SA for the study of meningococcemia (2006 and 2007)
Principal Investigators: Federico Martinon Torres and Antonio Salas Ellacuriaga


Collaboration agreement IDICHUS Foundation and Wyeth Pharmaceuticals SA for the study of mitochondrial DNA in meningococcal disease (2008)
Principal Investigators: Federico Martinon Torres
Peripheral Research Team:
• Dr. Jose María Martinón Sánchez
• Dr. Jose Manuel Sánchez Granados
• Dra. Olga Serrano Ayestarán
• Dr. Manuel Silveira Cancela
• Dr.Jose Luis García Rodriguez
• Dra. Susana María Rey García
• Dr. Valenti Pineda Solas
• Dra. Teresa Gili
• Dra. Cristina Calvo Monge
• Dra. Eider Oñate Vergara
• Dr. Cesar Pérez-Caballero Macarrón
• Dr. Jose Antonio Alonso Martín
• Dr. David Arjona Villanueba
• Dra. Pilar Azcón González de Aguilar
• Dr. Xavier Allúe Martínez
• Dr. Andrés Concha Torre
• Dr.Roberto Reig Saenz
• Dr. Francisco Giménez Sánchez
• Dr. Miguel Sánchez Forte
• Dr. Alfredo Repáraz Romero
• Dr. Manuel Ortiz Pallares
• Dr. Jesús de la Cruz Moreno
• Dra. M. Carmen Martínez Padilla
• Dra Carmen Santiago Gutierrez
• Dr. Vicente Modesto i Alapont
• Dr. Rafael Gómez Zafra
• Dr. Alvaro Castellanos Ortega
• Dr. Marcelino Pumarada
• Dr. Juan Casado Flores
• Dr. Sonia Marcos Alonso
• Dra. Angela Ferrer Barba
• Dra. Ana Hurtado Doce
• Dra. Amaya Bustinza Arriortua
• Dra. María Luisa Navarro Gómez
• Dra. Elizabeth Esteban Torné
• Dra. Sonia Cañadas Palazón
• Dr. Jose Manuel Gonzalez
• Dr. David Moreno
• Dr. Julio López Bayón
• Dra. Elvira Morteruel Arizkuren
• Dra. Soledad Martínez Regueira
• Dr. Juan Luis Pérez Navero
• Dra. María Teresa Alonso Salas
• Dra. María del Mar Ballesteros García
• Dr. Juan Ignacio Muñoz Bonet
• Dr. Servando Pantoja Rosso
• Dr. Enrique Bernaola Iturbe
• Dra. Concepción Goñi Orayen
• Dr. Francisco Alvarado Ortega
• Dra. Susana Reyes Dominguez
• Dra. Maria Cruz León León
• Dr. Juan Ignácio Sánchez Diaz
• Dra. Silvia Belda Hofheinz
• Dra. Natalia Molini Menchón
• Dra. Esther Ocete Hita
• Dr. Santiago Fernández Cebrián
• Dr. Mario Sánchez Fernández
• Dra. Isabel Quintela Fernández
• Dr. Rafael López Peña
• Dr. Eduardo Carreras Gonzalez
• Dra. Sonia Brio Sanagustin
• Dr. Jose Joaquin Dueñas Morales
• Dr. Jose Luaces Gonzalez
• Dr. Ramon Fernández Prieto
ESIGEM is part of the European research consortium on meningococcal disease (meningococcal Genetics Consortium)
Presenting the results of the first analysis of mitochondrial DNA in ESPID 2009 (27th annual meeting of the European Society for Pediatric Infectious Diseases (ESPID)) held in Brussels, June 9-13, 2009

PLoS ONE (in press): Salas A, Fachal L, Marcos-Alonso S, Vega A, Martinón-Torres F, et al. (2009) Investigating the Role of Mitochondrial Haplogroups in Genetic Predisposition to Meningococcal Disease. PLoS ONE 4(12): e8347. doi:10.1371/journal.pone.0008347, read article in en PLoS ONE. ESIGEM Research Group (Study on the genetic influence on Meningococcal Disease). Evaluating the Potential Role of Mitochondrial Haplogroups in Genetic Predisposition to Meningococcal Disease.

Nature Genetics: Davila S, Wright VJ, Khor CC, Lim KS, Binder A, Breunis WB, Inwald D, Nadel S, Betts H, Carrol E, de Groot R, Hazelzet J, Emonts M, Lim CC, Kuijpers TW, Martinon-Torres F, Salas A, Zenz W, Levin M, Hibberd ML, on behalf of the ESPID meningococcal genetics consortium.

NEW GENETIC VARIANTS IN THE CFH REGION ARE ASSOCIATED WITH HOST GENETIC SUSCEPTIBILITY TO MENINGOCOCCAL DISEASE.Nature Genetics 2010 (8 august 2010, epub ahead of print)

Próxima reunión del Meningococcal Genetic Consortium en Holanda, 15-17 septiembre de 2010

Procesos actualmente en marcha (resumen de "estado del arte" de ESIGEM)[aquí el link al resumen esigem aspectos claves)]
  • Finalización del GWAS ESIGEM (previsto Dic-2010)
  • Puesta en marcha de estudios funcionales simultáneos - "wholeomics" (Ago-2010)
  • Estudios severidad (inicio Ago-2010)
ESIGEM ASPECTOS CLAVES
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